This protocol was chosen in order to maximize the effect of shock waves on the development of collaterals. Collaterals develop usually within 2-3 weeks, which is the reason for the chosen intervals between treatments. In addition, animal studies found that maximal expression of angiogenic factors occur after 4 weeks. Also, clinical data, evaluating therapy on a weekly base, found that 3 weeks of treatments are the optimum dosage. This is in addition to the fact that this treatment protocol was developed and improved since first applied in 1998.