How can I know if the improvement in perfusion is the result of the therapeutic stimulated angiogenesis or due to the natural angiogenesis process in ischemic tissues?

Several results could confirm that the effect is true therapy and not “placebo” effect.  

• ESMR improved myocardial perfusion only in the region where SW’s were applied. Ischemic areas not treated stayed ischemic.  
• Patients treated have chronic stable angina class III or IV without change prior to treatment.  
• In vivo controlled studies confirm the significant increase in the number of collaterals at the treated zones compared to the non-treated ones.